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KMID : 0370219820260010025
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Yakhak Hoeji
1982 Volume.26 No. 1 p.25 ~ p.27
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Synthesis of 5-Fluorouracil by Ring Transformation of s-Triazine
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정원근/Chung WK
정진현/Chung JH
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Abstract
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We had reported that s-triazine can readily be converted into the corresponding 5-substituted pyrimidine. In order to develop new synthetic method of 5-fluorouracil, we tried to replace eliminating fragment, 1, 3-dimethylurea, by fluoroacetamide, which was expected to undergo nucleophilic attack by proton extraction of both alpha-hydrogen and aminohydrogen by lithium diisopropylamide (LDA). We found that 5-fluorouracil could be transformed from s-triazine under strong base condition like LDA as well as other 5-substituted pyrimidines.
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